Chemopreventive and therapeutic efficacy of silibinin against non-melanoma skin cancers
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Non-melanoma skin cancers (NMSCs) are a growing problem given that solar UVB radiation exposure is increasing due to depletion of the atmospheric ozone layer. Better preventive methods are urgently required to reduce UV-caused photodamage and incidence. There are two main types of NMSCs, squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs). One such agent that has shown promising efficacy against UVB-induced skin carcinogenesis, a model for SCCs, is the natural flavonolignan silibinin. Earlier, we have reported that silibinin activates p53 and reduces photodamage and SCCs, both in ...