Now showing items 1-10 of 11
Lysophosphatidic acid suppression of CD8 T cell signaling and function
Immunotherapies have demonstrated the utility of targeting the immune system for eradication of tumors, yet a majority of patients remain refractory to such treatments. Therefore, further advances in our understanding of ...
Use of a listeria monocytogenes protein to stimulate immune responses and anti-tumor effects
Author(s):Ortiz, Amber Leigh
Natural killer (NK) cells are a type of innate immune cell that secrete IFN when activated. IFN has pro-inflammatory effects and can act on tumor cells to kill them or inhibit their proliferation. NK cells can also exert ...
Regulation of myeloid cell IFNGR1 expression during infection and inflammatory disease, The
Author(s):Eshleman, Emily M.
IFNs target macrophages to regulate inflammation and resistance to microbial infections. The type II IFN (IFNγ) acts on a cell surface receptor (IFNGR) to promote gene expression that enhances macrophage pro-inflammatory ...
Functional roles of pulmonary dendritic cell subsets
Author(s):Desch, Ashley Nicole
Pulmonary dendritic cells (DCs) constantly sample tissue and traffic inhaled antigens to the lung-draining lymph node (LN) where they orchestrate an appropriate immune response. The immunologic outcome of antigen-presentation ...
Host-microbe interactions and epithelial immunity in the distal gut
The mammalian gastrointestinal tract harbors trillions of bacteria. A finely balanced mutualism exists within the intestinal mucosa, where microbes, essential for host health, can also initiate and perpetuate mucosal ...
Allergic B cells are central to establishing murine peanut allergy in an adoptive transfer model but are not required for maintaining long-lived serum immunoglobulin E levels
Peanut allergy, characterized by elevated anti-peanut IgE levels that are typically lifelong, is a growing problem worldwide. The role B cell subsets play in maintaining long-lived serum anti-peanut IgE levels in peanut-allergic ...
Clarification of the role of host DNA as a mediator of vaccine adjuvant activity
Author(s):Noges, Laura Evelyn
Aluminum salt (alum) adjuvants are widely used in human vaccination because they are safe and effective at generating antibody-mediated protective immunity. Though it is well known that alum induces T helper 2 responses ...
Expression, potency, and antiviral mechanisms of the interferon-alpha subtypes in retroviral infection
Author(s):Harper, Michael S.
More than 30 years after the first recognition of AIDS, HIV-1 infection remains an enormous public health burden globally. Understanding mechanisms of innate immunity to HIV-1 could fulfill the critical needs of novel ...
Defining how ubiquitination and neddylation regulate T cell receptor complex-mediated signaling
Post-translational modification provides the cell a dynamic method of regulating protein function in response to environmental signals. As with any cellular process, T cell receptor (TCR) complex-mediated signaling is ...
Contrasting roles of C/EBPα and notch in ionizing radiation-induced multipotent hematopoietic progenitor cell self-renewal defects
Author(s):Fleenor, Courtney Jo
Ionizing radiation (IR) is associated with persistent panhematopoietic defects and increased risk of carcinogenesis, although the mechanism underlying these relationship remains largely unknown. The increasing exposure of ...