Theses and Dissertations - School of Medicine
Recent Submissions
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Prospective exploration of the Woodcock-Johnson as a measure of neurocognitive-linguistic functioning in a cohort of collegiate athletes at high risk for sport-related concussion, A
Signs and symptoms of sport-related concussion can include cognitive dysfunction and are frequently treated by speech-language pathologist (SLPs). SLPs provide most cognitive rehabilitation in the United States, but report ... -
Role of JMJD5 and JMJD6 in transcriptional pause release, The
30-60% of genes in higher eukaryotes are regulated by promoter-proximal pausing of Pol II, thus representing a major transcription regulatory mechanism. Previously, we reported that two orphan Jumonji C domain (JmjC)-containing ... -
Genetic architecture of vitiligo and vitiligo subtypes, The
Vitiligo is an autoimmune disease that results in destruction of skin melanocytes and patches of white skin and hair. Family studies demonstrated a strong, but complex inherited basis for vitiligo. Subsequent genome-wide ... -
Cell-type specific inhibitory control of basolateral amygdala microcircuitry and plasticity
The basolateral amygdala plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons undergo plastic changes to encode this association; however, local basolateral ... -
Exploring the role of RET 5’ fusion partners in regulating signaling and response to therapy in novel RET-rearranged lung cancer models
RET rearrangements occur in 1-2% of lung adenocarcinomas as well as other malignancies and are promising targets for tyrosine kinase inhibitors. Non-small cell lung cancer patients with activating mutations in ALK, EGFR ... -
Intracellular and microglial immune response to flaviviral infection of the central nervous system, The
Flaviviruses cause the most cases of encephalitis in the world with the potential to cause significant morbidity and mortality. Of the Flaviviridae family, West Nile virus (WNV) and Japanese encephalitis virus (JEV) represent ... -
Signaling regulation of myelinating cells in the central nervous system
Oligodendrocytes produce an immense quantity of polarized membrane, myelin, that ensheaths axons in the central nervous system. Myelin facilitates efficient communication and also provides metabolic and trophic support to ... -
Comparison of one year post-injury outcomes between intensive locomotor training and conventional therapy after motor incomplete spinal cord injury
Background: Spinal cord injury (SCI) is often a devastating condition that negatively affects an individual’s physical, psychological, and social well-being requiring extensive rehabilitation. The majority of all SCIs are ... -
Investigation of traditional and deep neural sequence models for biomedical concept recognition
The goal of this dissertation is to improve state-of-the-art biomedical concept recognition. The task has a long history, but performance improvement is still an open research question. The dissertation has three main ... -
Lysophosphatidic acid suppression of CD8 T cell signaling and function
Immunotherapies have demonstrated the utility of targeting the immune system for eradication of tumors, yet a majority of patients remain refractory to such treatments. Therefore, further advances in our understanding of ... -
Human maternal obesity in the development of nonalcoholic fatty liver disease in a germ-free mouse model : identifying the role of the infant gut microbiome
Maternal metabolism and obesity contribute significantly to the risk of obesity and non-alcoholic fatty liver disease (NAFLD) in the next generation, however the causal drivers of this relationship are currently unclear. ... -
Pharmacokinetics and renal safety of tenofovir with ledipasvir/sofosbuvir
Individuals may be infected with Hepatitis C Virus (HCV) and the Human Immunodeficiency Virus (HIV) due to shared routes of transmission. HCV is curable with 8-12 weeks of direct-acting antiviral (DAA) therapy. However, ... -
High altitude pregnancy as a model for uteroplacental hypoxia : identifying therapeutic targets for preventing fetal growth restriction
Arguably a population with the greatest unmet need for therapies is pregnant women. Despite the risk of maternal and offspring perinatal morbidity and “programming” of adult disease in the offspring, there is a lack of ... -
Reward processing in healthy adolescents and adolescents with Anorexia nervosa
Anorexia nervosa (AN) is a severe eating disorder that predominantly affects young females and typically begins in adolescence. These studies aimed to understand the underlying neurobiology of adolescent AN by assessing ... -
Building a brain : interrogating how the α-tubulin gene TUBA1A contributes to neurodevelopment
The importance of microtubules during the development and appropriate function of the nervous system has long been acknowledged. The highly complex coordination of cell proliferation, differentiation, migration, neuronal ... -
Nuclear receptor regulation of a luminal breast cancer stem cell population
Crosstalk between nuclear receptors is emerging as important in regulating breast cancer (BC) treatment response and progression. Estrogen receptor (ER), progesterone receptor (PR), and retinoic acid receptor (RARα) are ... -
Developmental origins and heterogeneity of the neocortical oligodendrocyte lineage
The formation of neocortical circuits during development requires coordinated production of excitatory projection neurons, astrocytes, and oligodendrocytes from a shared pool of neural progenitor cells. While we are beginning ... -
Characterizing MIR137HG variation and contribution to risk for schizophrenia
The MIR137HG gene encoding microRNA-137 (miR-137) is associated with risk for schizophrenia (SZ) through genetic and functional studies, however, the molecular mechanisms underlying risk remain unknown. Through this work ... -
Mechanisms of immunoglobulin somatic hypermutation during retroviral infection
A potential HIV-1 vaccine should stimulate a broadly neutralizing antibody (bNAb) response, which overcomes HIV-1 mutational escape to typical NAb responses that develop by covering a wide variety of HIV-1 strains. bNAbs ... -
High incidence of SMAD4 loss and associated susceptibility to combined PARP inhibition with radiation in head and neck squamous cell carcinomas
SMAD4 loss is associated with increased survival and genomic instability, and contributes to the initiation/progression of head and neck squamous cell carcinoma (HNSCCs). SMAD4 loss, while not directly targetable, is ...
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