Theses and Dissertations - School of Medicine
Recent Submissions
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Discovery of small molecule inhibitors targeting oncogenic CHD1L with preclinical activity in colorectal cancer
The majority of colorectal cancers arise from dysregulation in the Wnt signaling pathway. Aberrant Wnt signaling is associated with tumor formation, metastasis, and drug resistance. Many current therapeutic strategies ... -
Variable IL-2Rβ expression and organization in signaling and disease
Delivery of recombinant IL-2 and IL-15 and the targeting of their receptors has emerged as a promising intervention strategy for treatment of autoimmunity, chronic infectious diseases and cancer. Therefore, a better ... -
Clinical utility of incorporating single-axis 3D tomography to the electron microscopic examination of ciliary biopsies, The
Primary ciliary dyskinesia (PCD) is a congenital disease of the respiratory airways characterized by abnormal cilia structure and function. Clinical symptoms of the disease may include situs inversus, bronchiectasis, and ... -
Tuba1a microtubules establish the foundations for neuronal function
Developing neurons undergo dramatic morphological changes to appropriately migrate and extend axons to make synaptic connections. The microtubule cytoskeleton, made of alpha/beta-tubulin dimers, drives neurite outgrowth, ... -
Novel requirements of the synaptic transmembrane protein Csmd2 in neuronal maturation and structural plasticity
The development and function of neural circuits is dependent on the coordinated expression of molecules that control how neurons develop the dendritic arbor and postsynaptic dendritic spines. Dysregulation of critical ... -
Gene expression patterns of gammaherpesviruses
Gammaherpesviruses (γHVs) are lymphotropic oncogenic viruses which include the human pathogens Kaposi’s sarcoma associated herpesvirus (KSHV) and Epstein-Barr virus, as well as the murine model murine gammaherpesvirus 68 ... -
CD44 mediates cancer stem cell and macrophage/monocyte interactions in head and neck cancer progression via stemness to invasion switch
Tumor-associated macrophages (TAMs) at the tumor-stromal interface (TSI) cooperate with cancer stem cells (CSCs) to maintain stemness. However, the molecular mechanisms underlying crosstalk between TAMs and CSCs in head ... -
Brain circuits underlying sensorimotor transformations
Sensorimotor transformations are orchestrated across many brain regions to produce adaptive behavior. A chief goal of systems neuroscience is to understand the unique computations and contributions made within this network. ... -
Transcriptional regulation of the developing retina
The retina is a complex stratified neural tissue required for all mammalian vision. During development, tightly controlled transcriptional regulation drives diversification from a homogenous population of retinal progenitor ... -
Targeting the SIX1/EYA complex in breast cancer metastasis
Metastasis is the number 1 killer of cancer patients and mis-regulation of developmental signaling pathways can dramatically affect this process. The SIX1/EYA transcriptional complex, a master early development regulator, ... -
Cerebellar control of reaching movements
Cerebellar dysfunction causes a unique decomposition of reaching movements, termed dysmetria. This oscillation of the limb during active movement is especially noticeable in the over- and under-shooting of target endpoint, ... -
Early determinants of CD8 T cell fate in the response to subunit immunization
While vaccination represents one of the most impactful developments in the history of medicine, successful vaccines still overwhelmingly rely on empirically-derived formulations targeting humoral responses. With the explosion ... -
Investigating adaptations to exercise that potentiate energy expenditure during weight regain
Metabolic adaptations established during weight loss maintenance accelerate weight regain by suppressing energy expenditure; therefore, interventions that increase energy expenditure during a relapse back to obesity may ... -
Biological implications of distinctive H3K79me2 patterns in acute myeloid leukemia
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are found in 20-30% of adult acute myeloid leukemia (AML). Wild type IDH1/2 produce a-ketoglutarate (aKG), an important co-factor for many enzymes including DNA, RNA, ... -
Semaphorin 7A drives breast cancer progression through intrinsic and extrinsic mechanisms
Breast cancer (BC) remains the second leading cause of cancer-related deaths for women in the US—mainly due to metastatic disease. Additionally, women aged <45 who are within 5-10 years of most recent childbirth at BC ... -
Performance of a rules-based, electronic health record-driven severe asthma case finding algorithm for clinical trial recruitment
Background Clinical trial recruitment is inefficient. New, more efficient and phenotype-targeted recruitment strategies require analysis of electronic health record data to automate severe asthma case finding. Objective ... -
Investigation of approaches to implementing effective clinical decision support within electronic health records
Clinical decision support (CDS) within electronic health records (EHR) is one approach to optimize healthcare outcomes, but the full potential is unrealized. Others have hypothesized that CDS design best practices can ... -
Pathways controlling response to immune checkpoint inhibitors in non-small cell lung cancer
Targeting PD-1/PD-L1 is only effective in ∼20% of lung cancer patients, but determinants of this response are poorly defined. We previously observed differential responses of two murine KRAS–mutant lung cancer cell lines ... -
Sex differences in response to forced-treadmill exercise
Obesity is a global health problem that affects individuals of every age, sex, ethnicity, race, and socioeconomic status, however, there is a greater prevalence of obesity in women. Despite numerous well-known aspects of ... -
Role of EZH2 in group 3 medulloblastoma, The
Medulloblastoma is a tumor of the posterior fossa (cerebellum) occurring mostly in children under nine years of age. Amongst brain cancers it is the most common solid tumor in childhood and has the most frequent occurrence ...
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