Theses and Dissertations - School of Medicine
Recent Submissions
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Induction of antigen-specific tolerance in autoimmune diabetes using a hybrid insulin peptide
T cells play a critical role in promoting the development of autoimmunity in Type 1 Diabetes (T1D) patients and the non-obese diabetic (NOD) mouse model. The CD4+ T cell clone BDC-2.5, originally isolated from a NOD mouse, ... -
Role of microRNA-126 in lung microvascular endothelial cells
Endothelial specific microRNA-126 (miR-126) is required for angiogenesis during development and repair of injured arterial vasculature in adult. Endothelial cells are a diverse group of cells with distinct molecular and ... -
HIV TAT mediation of redox sensitive transcription factors in pulmonary vascular cells
Chronic HIV infection in the era of anti-retroviral therapy is associated with dramatically increased risk of developing severe cardio-pulmonary disease. Common to these diseases are increased oxidative burden and chronic ... -
Single cell analysis of biochemical phenotypes
Recent development of high throughput single cell methods has expanded our understanding of tissue heterogeneity, cell states, and developmental biology. Current single cell methods aim to understand cell function and ... -
Interactions at the interface- mechanisms of capsular polysaccharide communication with the host in intestinal bacteroides
Millenia of co-evolution have shaped the relationships between humans and microbes, and signatures of these interactions can be found in the physiology of each. This thesis looks directly at host and microbial factors at ... -
TGFβ-androgen receptor signaling axis affects anoikis resistance in triple negative breast cancer, A
These studies were intended to identify a mechanism through which the TGFβ signaling pathway increases androgen receptor (AR) under anchorage independent conditions to promote anoikis resistance in triple-negative breast ... -
Gut microbiome composition in individuals infected with HIV and high-risk men who have sex with men and the implications for chronic inflammation and metabolic co-morbidity
The gut microbiome has a vast ability to influence human health. The microbiome’s influence is of particular interest in people living with HIV. HIV infection targets and depletes gut immune cells resulting in a change of ... -
Deep artificial neural network models of neural encoding in vision and neurostimulation
There is a significant need for more effective treatments for neurological and psychiatric diseases. Implantable neurostimulators are increasingly used as new therapeutic options for these diseases. This work will discuss ... -
Chronic interleukin-1 exposure triggers selective expansion of CEBPA-deficient multipotent hematopoietic progenitors
The early events that drive hematologic disorders like clonal hematopoiesis, myelodysplastic syndrome, myeloproliferative neoplasm, and acute myeloid leukemia are not well understood. Most studies focus on the cell-intrinsic ... -
Role of the tumor microenvironment on the progression of lung cancer, The
Lung cancer is the leading cause of cancer-related deaths, with an overall 5-year survival rate of less than 18%. Interactions between cancer cells and the tumor microenvironment (TME) can affect tumor progression. The TME ... -
Role of poly/autoreactive B cells in the protective immune response, The
Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. ... -
Mechanistic studies of GCN5 acetylation during craniofacial development and chondrocyte maturation
Formation of the craniofacial skeleton involves the invasion of the migratory cranial neural crest (cNCC) into the pharyngeal arches, where they will terminally differentiate and contribute to the bone and cartilage that ... -
Discovery of small molecule inhibitors targeting oncogenic CHD1L with preclinical activity in colorectal cancer
The majority of colorectal cancers arise from dysregulation in the Wnt signaling pathway. Aberrant Wnt signaling is associated with tumor formation, metastasis, and drug resistance. Many current therapeutic strategies ... -
Variable IL-2Rβ expression and organization in signaling and disease
Delivery of recombinant IL-2 and IL-15 and the targeting of their receptors has emerged as a promising intervention strategy for treatment of autoimmunity, chronic infectious diseases and cancer. Therefore, a better ... -
Clinical utility of incorporating single-axis 3D tomography to the electron microscopic examination of ciliary biopsies, The
Primary ciliary dyskinesia (PCD) is a congenital disease of the respiratory airways characterized by abnormal cilia structure and function. Clinical symptoms of the disease may include situs inversus, bronchiectasis, and ... -
Tuba1a microtubules establish the foundations for neuronal function
Developing neurons undergo dramatic morphological changes to appropriately migrate and extend axons to make synaptic connections. The microtubule cytoskeleton, made of alpha/beta-tubulin dimers, drives neurite outgrowth, ... -
Novel requirements of the synaptic transmembrane protein Csmd2 in neuronal maturation and structural plasticity
The development and function of neural circuits is dependent on the coordinated expression of molecules that control how neurons develop the dendritic arbor and postsynaptic dendritic spines. Dysregulation of critical ... -
Gene expression patterns of gammaherpesviruses
Gammaherpesviruses (γHVs) are lymphotropic oncogenic viruses which include the human pathogens Kaposi’s sarcoma associated herpesvirus (KSHV) and Epstein-Barr virus, as well as the murine model murine gammaherpesvirus 68 ... -
CD44 mediates cancer stem cell and macrophage/monocyte interactions in head and neck cancer progression via stemness to invasion switch
Tumor-associated macrophages (TAMs) at the tumor-stromal interface (TSI) cooperate with cancer stem cells (CSCs) to maintain stemness. However, the molecular mechanisms underlying crosstalk between TAMs and CSCs in head ... -
Targeting the SIX1/EYA complex in breast cancer metastasis
Metastasis is the number 1 killer of cancer patients and mis-regulation of developmental signaling pathways can dramatically affect this process. The SIX1/EYA transcriptional complex, a master early development regulator, ...
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