Theses and Dissertations - School of Medicine
Recent Submissions
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Biological implications of distinctive H3K79me2 patterns in acute myeloid leukemia
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are found in 20-30% of adult acute myeloid leukemia (AML). Wild type IDH1/2 produce a-ketoglutarate (aKG), an important co-factor for many enzymes including DNA, RNA, ... -
Semaphorin 7A drives breast cancer progression through intrinsic and extrinsic mechanisms
Breast cancer (BC) remains the second leading cause of cancer-related deaths for women in the US—mainly due to metastatic disease. Additionally, women aged <45 who are within 5-10 years of most recent childbirth at BC ... -
Performance of a rules-based, electronic health record-driven severe asthma case finding algorithm for clinical trial recruitment
Background Clinical trial recruitment is inefficient. New, more efficient and phenotype-targeted recruitment strategies require analysis of electronic health record data to automate severe asthma case finding. Objective ... -
Investigation of approaches to implementing effective clinical decision support within electronic health records
Clinical decision support (CDS) within electronic health records (EHR) is one approach to optimize healthcare outcomes, but the full potential is unrealized. Others have hypothesized that CDS design best practices can ... -
Pathways controlling response to immune checkpoint inhibitors in non-small cell lung cancer
Targeting PD-1/PD-L1 is only effective in ∼20% of lung cancer patients, but determinants of this response are poorly defined. We previously observed differential responses of two murine KRAS–mutant lung cancer cell lines ... -
Sex differences in response to forced-treadmill exercise
Obesity is a global health problem that affects individuals of every age, sex, ethnicity, race, and socioeconomic status, however, there is a greater prevalence of obesity in women. Despite numerous well-known aspects of ... -
Role of EZH2 in group 3 medulloblastoma, The
Medulloblastoma is a tumor of the posterior fossa (cerebellum) occurring mostly in children under nine years of age. Amongst brain cancers it is the most common solid tumor in childhood and has the most frequent occurrence ... -
Epigenetic and Co-transcriptional regulation of B lymphocyte development and function
B lymphocyte development and function are tightly regulated processes that are dependent on appropriate expression of lineage- and developmental stage-specific transcriptional programs. Several factors contribute to the ... -
Identifying targets for improved activity and participation after dysvascular and traumatic amputation in middle age or older
People with dysvascular and traumatic etiology of lower-limb amputation (LLA) in middle age or later report severe disability with conventional rehabilitation approaches that primarily target the use of a prosthesis. ... -
Regulation of myeloid cell IFNGR1 by types I and II interferon, The
Types I and type II interferon (IFNα/β and IFNγ) are cytokines that are critical mediators of myeloid cell activity during immune responses. The type II IFN (IFNγ) binds IFNGR to regulate myeloid cell gene expression and ... -
Convergence and evolving amino acid propensities
Understanding the relationship between structure and function of proteins is essential for studying protein dysfunction and disease and for engineering therapeutic proteins with novel functions. The details of how proteins ... -
Inflammatory cytokines as critical regulators of hematopoiesis and leukemia progression
Chronic inflammation, often driven by the pro-inflammatory cytokine IL-1, is commonly found in patients with auto-immune disorders, hematological malignancies, or obesity, as well as in aging individuals. Hematopoietic ... -
Identifying rare somatic mutations as a means of understanding tissue clonal evolution
Many general principles governing the development and evolution of cancers have been discovered by measuring how cells within tumors evolve with time. It is however still largely unclear what first steps a cell population ... -
Gene set enrichment analysis to understand context-specific gene expression
Measuring gene expression, or the genome-wide levels of mRNA molecules in a human cell, provides a rich source of information about the functional pathways and processes active or dysregulated in the cell. Gene expression ... -
Putting more neural in artificial neural networks
In computational neuroscience, we are at the intersection of neuroscience and artificial intelligence (AI). In this thesis, we work towards understanding how can we use AI algorithms as a model of the brain, and how can ... -
Modifications to TRPM2 channel activity following global cerebral ischemia
TRPM2 is a calcium permeable channel activated by ADPR metabolites and oxidative stress. TRPM2 contributes to neuronal injury in the brain caused by stroke and cardiac arrest among other diseases including cancer, inflammation, ... -
Regulation of cell division and roles for the post-mitotic midbody, The
Cell division is one of the most intricate and well-orchestrated events in the life of a cell. Ultimately, the separation of genetic material into the two daughter cells relies on smaller events within mitosis, such as ... -
Prospective exploration of the Woodcock-Johnson as a measure of neurocognitive-linguistic functioning in a cohort of collegiate athletes at high risk for sport-related concussion, A
Signs and symptoms of sport-related concussion can include cognitive dysfunction and are frequently treated by speech-language pathologist (SLPs). SLPs provide most cognitive rehabilitation in the United States, but report ... -
Role of JMJD5 and JMJD6 in transcriptional pause release, The
30-60% of genes in higher eukaryotes are regulated by promoter-proximal pausing of Pol II, thus representing a major transcription regulatory mechanism. Previously, we reported that two orphan Jumonji C domain (JmjC)-containing ... -
Genetic architecture of vitiligo and vitiligo subtypes, The
Vitiligo is an autoimmune disease that results in destruction of skin melanocytes and patches of white skin and hair. Family studies demonstrated a strong, but complex inherited basis for vitiligo. Subsequent genome-wide ...
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