Now showing items 11-20 of 519
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Role of formin cytoskeletal effector proteins in T cell migration and autoimmune disease, The
Author(s):Thompson, Scott Beckett
T cells must traffic through the bloodstream to sites of inflammation to execute their effector function. To enter tissues, T cells extravasate through the vascular endothelial cell wall by a process known as transendothelial ...
Targeting cell intrinsic and extrinsic mechanisms involved in the initiation and maintenance of non-small cell lung cancer
Despite advancements in understanding the molecular underpinnings involved in the pathogenesis of lung cancer, it remains the leading cause of cancer-related deaths worldwide. While the revolution of targeted therapies has ...
Lysophosphatidic acid suppression of CD8 T cell signaling and function
Immunotherapies have demonstrated the utility of targeting the immune system for eradication of tumors, yet a majority of patients remain refractory to such treatments. Therefore, further advances in our understanding of ...
Building and breaking down the blood-brain barrier
The fine tuning of cellular events and regulatory signals during vascular development in the central nervous system (CNS) is emerging as an important facet of brain vascular health and function. Through these complex events ...
Immunomodulatory effects of the short chain fatty acid butyrate on gut mucosal T cells in the setting of HIV-1 infection
The gastrointestinal tract is profoundly affected during acute and chronic HIV-1 infection. Early in the course of the infection, there is a breakdown in gut epithelial barrier integrity, high levels of viral replication, ...
Role of diet in male veterans with Multiple Sclerosis, The
Author(s):Hadidi, Daniel Armon
Multiple Sclerosis (MS) is a chronic, autoimmune disease affecting over 400,000 Americans, in which recurrent inflammation destroys myelin forming cells (oligodendroglia), axons, neurons and astrocytes resulting in a variety ...
Detecting and understanding microbiome and metabolome interactions via networks
Microbiomes are communities of bacteria. These communities exist in a variety of places ranging from soil and the ocean to various locations on the human body. Next generation sequencing technologies have made it possible ...
RNA Pol II cleavage activity is a major effector of transcription dynamics
Author(s):Sheridan, Ryan Michael
After transcription initiation, RNA polymerase II (pol II) undergoes several steps that can influence gene expression, including promoter proximal pausing, transcription elongation, and termination. Promoter proximal pausing ...
Transforming rehabilitation for older adults following hospitalization
The functional decline in older adult populations following hospitalization is a growing public health concern given the expected rise in the older adult population and the associated resources needed for their care. Nearly ...
Mechanisms that impact DNA-dependent activities of human mitochondrial transcription factor A
The mitochondrion is best known as the energy transducing organelle responsible for generating adenosine triphosphate that the cell requires for life. Transcription and compaction of the multicopy mitochondrial genome is ...