Now showing items 1-10 of 17
Role of formin cytoskeletal effector proteins in T cell migration and autoimmune disease, The
Contributor:Thompson, Scott Beckett
T cells must traffic through the bloodstream to sites of inflammation to execute their effector function. To enter tissues, T cells extravasate through the vascular endothelial cell wall by a process known as transendothelial ...
Professional APCs are involved in the recruitment and activation of T cells within the islets during Type 1 diabetes progression
Contributor:Sandor, Adam Miklos
Type 1 diabetes (T1D) is caused by the T cell mediated autoimmune destruction of the insulin-producing β cells within the pancreatic islets. Along with T cells, professional antigen presenting cells (APCs) are also required ...
TCR signaling affects the development of thymic NKT cell subsets
Contributor:Tuttle, Kathryn Dawn
NKT cells are a class of αβ T cells that express a semi-invariant T Cell Receptor (TCR) and recognize glycolipids presented by the non-polymorphic MHC molecule, CD1d. NKT cells are considered to be innate-like lymphocytes ...
Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and functionality of surviving CD8+ T cells
It is common practice for researchers to use antibodies to remove a specific cell type to infer its function. However, it is difficult to completely eliminate a cell type and there is often limited or no information as to ...
Tryptophan catabolizing enzyme TDO2 as an immunotherapeutic target in breast cancer, The
Tryptophan catabolism is an attractive target for reducing tumor progression and improving antitumor immunity in multiple cancers. In triple-negative breast cancer (TNBC), tumor infiltration by CD8 T cells correlates with ...
Structural and mechanistic analysis of IRES driven translation initiation from the 5' leaders of HIV-1 transcripts
Internal ribosome entry site (IRES) RNAs are important regulators of gene expression, but their diverse molecular mechanisms remain partially understood. The HIV-1 gag transcript leader contains an IRES that may be a good ...
Immunological mechanisms of pancreatic islet transplant rejection in autoimmune diabetic mice
Contributor:Burrack, Adam Lee
Type 1 diabetes (T1D) is a T cell-dependent autoimmune disease resulting from the destruction of insulin producing beta cells in the pancreas. Pancreatic islet transplantation is a potentially curative therapy for this ...
Regulation of invariant NKT cell selection and development
Natural Killer T (NKT) cells are a unique subset of T lymphocytes that have been implicated in both promoting and suppressing a multitude of immune responses. In mice, NKT cells express T cell antigen receptors (TCRs) ...
Identification of a novel post-translationally modified antigen in the NOD mouse model of autoimmune diabetes
Contributor:Wiles, Timothy Aaron
Autoimmunity arises from a failure of the immune system to establish or maintain self-tolerance. In the thymus, developing T cells are exposed to self-peptides derived from genetically encoded proteins, and self-reactive ...
T cell trafficking and function changes during Type 1 diabetes progression
Contributor:Lindsay, Robin Sean
Type 1 diabetes (T1D) is an autoimmune disease resulting from primarily T cell mediated destruction of pancreatic islet β-cells. To initiate β-cell destruction T cells must first be able to enter the islets. Changes in T ...