Now showing items 1-10 of 12
Precision therapeutic approach to autoimmunity caused by PI3K pathway dysregulation, A
Author(s):Franks, Sarah Elizabeth
GWAS and candidate studies have identified risk-conferring allelic variants that impair the ability to maintain immune tolerance. Several of these risk alleles are thought to function in B cell signaling, including negative ...
Professional APCs are involved in the recruitment and activation of T cells within the islets during Type 1 diabetes progression
Author(s):Sandor, Adam Miklos
Type 1 diabetes (T1D) is caused by the T cell mediated autoimmune destruction of the insulin-producing β cells within the pancreatic islets. Along with T cells, professional antigen presenting cells (APCs) are also required ...
Epigenetic and Co-transcriptional regulation of B lymphocyte development and function
B lymphocyte development and function are tightly regulated processes that are dependent on appropriate expression of lineage- and developmental stage-specific transcriptional programs. Several factors contribute to the ...
Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and functionality of surviving CD8+ T cells
It is common practice for researchers to use antibodies to remove a specific cell type to infer its function. However, it is difficult to completely eliminate a cell type and there is often limited or no information as to ...
Role of ETV6 germline mutations in B cell development and predisposition to leukemia, The
Acute lymphoblastic leukemia is the most common cancer in children, and the tumor suppressor ETV6 has long been associated with the disease, most commonly as part of the ETV6-RUNX1 translocation. Our group and others ...
Regulation of central B cell selection by the ERK and PI3K signaling pathways
In some patients with autoimmune diseases, autoreactive B cells are able to bypass central tolerance mechanisms to escape into the periphery and promote disease. A better understanding of the molecular pathways that control ...
B cell subset contributions to the primary HIV antibody response
Despite global efforts, a preventative HIV vaccine remains elusive. The correlates of protection against HIV infection are as yet undefined, but clues can be drawn from potent antibodies able to neutralize diverse HIV ...
TRPM2 and L-type voltage-gated calcium channels as regulator of immunity
Ca²⁺ as a versatile second messenger participates in a wide range of physiological and pathological responses in all cells of the immune system. To regulate Ca²⁺ signaling, immune cells express a network of Ca²⁺ -permeable ...
Viral and host determinants of Chikungunya virus persistence
Chikungunya virus (CHIKV) is a mosquito-transmitted arthritogenic alphavirus that is a global public health burden. In 2013, CHIKV spread from the Eastern Hemisphere to the Americas where it has since spread to 45 countries ...
Surface IgM modulation maintains low-affinity, self-reactive follicular B cells in a responsive state
Author(s):Kirchenbaum, Greg Adam
Somatic gene rearrangement generates a diverse repertoire of B cell receptors (BCR), including BCR possessing a range of affinities for self-antigen. Newly generated B cells express high and relatively uniform amounts of ...