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Induction of antigen-specific tolerance in autoimmune diabetes using a hybrid insulin peptide
T cells play a critical role in promoting the development of autoimmunity in Type 1 Diabetes (T1D) patients and the non-obese diabetic (NOD) mouse model. The CD4+ T cell clone BDC-2.5, originally isolated from a NOD mouse, ... -
Role of microRNA-126 in lung microvascular endothelial cells
Endothelial specific microRNA-126 (miR-126) is required for angiogenesis during development and repair of injured arterial vasculature in adult. Endothelial cells are a diverse group of cells with distinct molecular and ... -
Afghanistan desert particulate matter promotes inflammatory signaling and airway hyperresponsiveness
Since the start of post-September 11th, 2001 combat operations in Afghanistan, increasing numbers of soldiers have returned from deployment with symptoms consistent with an asthma-like airways disease. This Deployment ... -
HIV TAT mediation of redox sensitive transcription factors in pulmonary vascular cells
Chronic HIV infection in the era of anti-retroviral therapy is associated with dramatically increased risk of developing severe cardio-pulmonary disease. Common to these diseases are increased oxidative burden and chronic ... -
Single cell analysis of biochemical phenotypes
Recent development of high throughput single cell methods has expanded our understanding of tissue heterogeneity, cell states, and developmental biology. Current single cell methods aim to understand cell function and ... -
PAH mixture exposures may drive mixture specific monocyte immune responses through modifications to monocyte metabolomes
Generated during incomplete combustion of carbon sources, polycyclic aromatic hydrocarbons (PAHs) have been shown to lead to both lung and digestive tract cancers. Exposures to benzo[a]pyrene (B[a]P), a group I carcinogen ... -
Evaluation of cannabis ICD-10-CM codes' performance to predict emergency department visits partially attributable to cannabis
Background: Colorado became the first state to legalize and implement recreational cannabis sales in the United States. Research is needed to understand the public health implications of recreational cannabis legalization ... -
Interactions at the interface- mechanisms of capsular polysaccharide communication with the host in intestinal bacteroides
Millenia of co-evolution have shaped the relationships between humans and microbes, and signatures of these interactions can be found in the physiology of each. This thesis looks directly at host and microbial factors at ... -
TGFβ-androgen receptor signaling axis affects anoikis resistance in triple negative breast cancer, A
These studies were intended to identify a mechanism through which the TGFβ signaling pathway increases androgen receptor (AR) under anchorage independent conditions to promote anoikis resistance in triple-negative breast ... -
Examining the effect of adding community-based palliative care on the health-related quality of life of individuals with severe chronic obstructive pulmonary disease dissertation
Background: Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and the 5th leading cause of mortality worldwide, affecting more than 200 million people. COPD patients have high rates of healthcare ... -
Clinical and economic impact of high short-acting β-agonist use in patients with persistent asthma
High Short-Acting β−Agonists (SABA) use is an important indicator of poor asthma control and has been utilized in various studies as a proxy measure of asthma control for various purposes (e.g. predictive marker for future ... -
Parents' perceptions about offspring's mental health care
The two most often identified mental health issues in adolescents are anxiety and mood disorders, including depression. The level of undetected mental health disorders in this population remains extraordinarily high. Parents ... -
Examining the association of sociotechnical factors on antibiotic delays in the intensive care unit (ICU)
This retrospective exploratory study examines the associations between the technical systems (labor resources, material resources, communication and teamwork) and the social system (nursing years of experience and ... -
Statistical methodology for computed tomography scans of the lung
As computed tomography (CT) scans of the lung become more widely used for clinical research, methods that can meaningfully identify population-level features across lung images are needed. Approaches to characterize lung ... -
Development of a statistical modeling and surveillance framework for postmarket drug prescribing and risk-mitigation behavior
The FDA is authorized to approve important, high risk drugs by requiring Risk Evaluation and Mitigation Strategies (REMS) to manage risk. The most restrictive policies in a REMS are Elements to Assure Safe Use. Currently, ... -
Gut microbiome composition in individuals infected with HIV and high-risk men who have sex with men and the implications for chronic inflammation and metabolic co-morbidity
The gut microbiome has a vast ability to influence human health. The microbiome’s influence is of particular interest in people living with HIV. HIV infection targets and depletes gut immune cells resulting in a change of ... -
Deep artificial neural network models of neural encoding in vision and neurostimulation
There is a significant need for more effective treatments for neurological and psychiatric diseases. Implantable neurostimulators are increasingly used as new therapeutic options for these diseases. This work will discuss ... -
Chronic interleukin-1 exposure triggers selective expansion of CEBPA-deficient multipotent hematopoietic progenitors
The early events that drive hematologic disorders like clonal hematopoiesis, myelodysplastic syndrome, myeloproliferative neoplasm, and acute myeloid leukemia are not well understood. Most studies focus on the cell-intrinsic ... -
Role of the tumor microenvironment on the progression of lung cancer, The
Lung cancer is the leading cause of cancer-related deaths, with an overall 5-year survival rate of less than 18%. Interactions between cancer cells and the tumor microenvironment (TME) can affect tumor progression. The TME ... -
Role of poly/autoreactive B cells in the protective immune response, The
Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. ...
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