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Is collaboration between nonprofit hospitals and local health departments effective? An analysis of hospital community benefit activities
Nonprofit hospitals (NFP) must provide certain types of community benefit (CB) in order to keep their tax-exempt status. The IRS reported that NFPs spent over $60 billion on CB activities in 2011. NFPs have dedicated most ... -
Biological implications of distinctive H3K79me2 patterns in acute myeloid leukemia
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are found in 20-30% of adult acute myeloid leukemia (AML). Wild type IDH1/2 produce a-ketoglutarate (aKG), an important co-factor for many enzymes including DNA, RNA, ... -
Semaphorin 7A drives breast cancer progression through intrinsic and extrinsic mechanisms
Breast cancer (BC) remains the second leading cause of cancer-related deaths for women in the US—mainly due to metastatic disease. Additionally, women aged <45 who are within 5-10 years of most recent childbirth at BC ... -
Performance of a rules-based, electronic health record-driven severe asthma case finding algorithm for clinical trial recruitment
Background Clinical trial recruitment is inefficient. New, more efficient and phenotype-targeted recruitment strategies require analysis of electronic health record data to automate severe asthma case finding. Objective ... -
Investigation of approaches to implementing effective clinical decision support within electronic health records
Clinical decision support (CDS) within electronic health records (EHR) is one approach to optimize healthcare outcomes, but the full potential is unrealized. Others have hypothesized that CDS design best practices can ... -
Effects of missing data on outcome-dependent sampling methods for longitudinal cohorts with binary data
With the increasing availability of longitudinal cohort study data and associated biospec- imen libraries, retrospective testing of stored samples to address hypotheses beyond the original aims of the cohort study has ... -
Pathways controlling response to immune checkpoint inhibitors in non-small cell lung cancer
Targeting PD-1/PD-L1 is only effective in ∼20% of lung cancer patients, but determinants of this response are poorly defined. We previously observed differential responses of two murine KRAS–mutant lung cancer cell lines ... -
Mixed-methods approach to characterizing cross-sector collaboration and its effects in nurse-family partnership, A
Statement of the Problem: Pregnant women living in poverty are at risk for adverse pregnancy outcomes. Children born to women living in poverty are also at greatest risk for poor health and development. Nurse-Family ... -
Sex differences in response to forced-treadmill exercise
Obesity is a global health problem that affects individuals of every age, sex, ethnicity, race, and socioeconomic status, however, there is a greater prevalence of obesity in women. Despite numerous well-known aspects of ... -
Role of EZH2 in group 3 medulloblastoma, The
Medulloblastoma is a tumor of the posterior fossa (cerebellum) occurring mostly in children under nine years of age. Amongst brain cancers it is the most common solid tumor in childhood and has the most frequent occurrence ... -
Applications of susceptible infectious recovered models for measles risk in Colorado schools and childcare centers
Measles was considered eliminated in the U.S. in 2000, but in the first 7 months of 2019 there have been over 1,100 reported cases. Many states, including Colorado, allow for non-medical exemptions (NMEs) to vaccinations ... -
Predictors of continuous glucose monitoring use in adolescents with type 1 diabetes
Background: Type 1 diabetes (T1D) requires lifelong insulin injections and glucose monitoring to reduce long term health complications. Adolescents have the poorest glycemic control of all individuals with T1D, and have ... -
Identifying targets for improved activity and participation after dysvascular and traumatic amputation in middle age or older
People with dysvascular and traumatic etiology of lower-limb amputation (LLA) in middle age or later report severe disability with conventional rehabilitation approaches that primarily target the use of a prosthesis. ... -
Epigenetic and Co-transcriptional regulation of B lymphocyte development and function
B lymphocyte development and function are tightly regulated processes that are dependent on appropriate expression of lineage- and developmental stage-specific transcriptional programs. Several factors contribute to the ... -
Proteomic insights into acylation events in alcoholic liver disease and heart failure
Protein post translational modifications (PTMs) and their regulatory enzymes play a significant role in health and disease. The research undertaken in this dissertation involves the application of a novel mass spectrometry ... -
Regulation of myeloid cell IFNGR1 by types I and II interferon, The
Types I and type II interferon (IFNα/β and IFNγ) are cytokines that are critical mediators of myeloid cell activity during immune responses. The type II IFN (IFNγ) binds IFNGR to regulate myeloid cell gene expression and ... -
Convergence and evolving amino acid propensities
Understanding the relationship between structure and function of proteins is essential for studying protein dysfunction and disease and for engineering therapeutic proteins with novel functions. The details of how proteins ... -
Inflammatory cytokines as critical regulators of hematopoiesis and leukemia progression
Chronic inflammation, often driven by the pro-inflammatory cytokine IL-1, is commonly found in patients with auto-immune disorders, hematological malignancies, or obesity, as well as in aging individuals. Hematopoietic ... -
Identifying rare somatic mutations as a means of understanding tissue clonal evolution
Many general principles governing the development and evolution of cancers have been discovered by measuring how cells within tumors evolve with time. It is however still largely unclear what first steps a cell population ... -
Gene set enrichment analysis to understand context-specific gene expression
Measuring gene expression, or the genome-wide levels of mRNA molecules in a human cell, provides a rich source of information about the functional pathways and processes active or dysregulated in the cell. Gene expression ...
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