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Prospective exploration of the Woodcock-Johnson as a measure of neurocognitive-linguistic functioning in a cohort of collegiate athletes at high risk for sport-related concussion, A
Signs and symptoms of sport-related concussion can include cognitive dysfunction and are frequently treated by speech-language pathologist (SLPs). SLPs provide most cognitive rehabilitation in the United States, but report ... -
Risk of ventricular arrhythmias/cardiac arrest associated with selective serotonin reuptake inhibitor (SSRI) use among pediatric and young adult population
Selective serotonin reuptake inhibitors (SSRIs) have been associated with increased risk of QT prolongation and life-threatening arrhythmia. Despite being the most commonly prescribed antidepressant, the risk of this adverse ... -
Role of JMJD5 and JMJD6 in transcriptional pause release, The
30-60% of genes in higher eukaryotes are regulated by promoter-proximal pausing of Pol II, thus representing a major transcription regulatory mechanism. Previously, we reported that two orphan Jumonji C domain (JmjC)-containing ... -
Drug disposition in glomerular kidney diseases
Glomerular kidney diseases comprise a group of diseases that affect the glomerulus or filtration apparatus of the nephron. The dissertation is focused on drug disposition in two glomerular kidney diseases, namely systemic ... -
Critical discourse analysis of acute care medical-surgical nurse discourses surrounding patient-focused safety voice behaviors from a caring science perspective, A
The purposes of this critical discourse analysis are to illuminate the dominant discourses exhibited by medical-surgical nurses when discussing times when they have or have not engaged in patient-focused safety voice ... -
Associations between payment reforms and cardiac rehabilitation in traditional Medicare beneficiaries : use of cardiac rehabilitation following payment incentives and penalties, and its relationship to 30-day all-cause readmission ratios
Background Cardiac rehabilitation (CR) is an outpatient, exercise-based prevention strategy with Class I Guideline recommendations. However, only 10-30% of eligible Medicare beneficiaries begin CR treatment following ... -
Genetic architecture of vitiligo and vitiligo subtypes, The
Vitiligo is an autoimmune disease that results in destruction of skin melanocytes and patches of white skin and hair. Family studies demonstrated a strong, but complex inherited basis for vitiligo. Subsequent genome-wide ... -
Cell-type specific inhibitory control of basolateral amygdala microcircuitry and plasticity
The basolateral amygdala plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons undergo plastic changes to encode this association; however, local basolateral ... -
Heart failure disease management in skilled nursing facilities
Heart failure disease management (HF-DM) in skilled nursing facilities (SNF) is challenging because of the medical complexity of the patients and quality problems in SNFs, including high staff turnover rates, frequent ... -
Exploring the role of RET 5’ fusion partners in regulating signaling and response to therapy in novel RET-rearranged lung cancer models
RET rearrangements occur in 1-2% of lung adenocarcinomas as well as other malignancies and are promising targets for tyrosine kinase inhibitors. Non-small cell lung cancer patients with activating mutations in ALK, EGFR ... -
Signaling regulation of myelinating cells in the central nervous system
Oligodendrocytes produce an immense quantity of polarized membrane, myelin, that ensheaths axons in the central nervous system. Myelin facilitates efficient communication and also provides metabolic and trophic support to ... -
Intracellular and microglial immune response to flaviviral infection of the central nervous system, The
Flaviviruses cause the most cases of encephalitis in the world with the potential to cause significant morbidity and mortality. Of the Flaviviridae family, West Nile virus (WNV) and Japanese encephalitis virus (JEV) represent ... -
Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules
A hallmark of the adaptive immune system in jawed vertebrates is its ability to generate a diverse collection of antigen receptors with numerous specificities. Such diversity improves species fitness by affording individuals ... -
Six2 mediates late stage metastasis via direct regulation of SOX2 and induction of a cancer stem cell program
The capacity for tumor cells to metastasize efficiently is directly linked to their ability to colonize secondary sites. Here we identify Six2, a developmental transcription factor, as a critical regulator of a breast ... -
From models to mechanisms : the pathogenesis and treatment of enterovirus D68-induced acute flaccid myelitis
In an effort to understand the paralytic disease caused by enterovirus D68 (EV-D68), we have developed a novel neonatal mouse model of infection that recapitulates many of the features of EV-D68-associated acute flaccid ... -
Understanding the role of AKAP150 palmitoylation in synaptic plasticity
Ca2+-permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term potentiation (LTP), but mechanisms regulating ... -
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The Iron Lung
The Iron Lung is a tank respirator used to artificially keep a polio patient breathing.
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