Synthetic endocannabinoids reduce Sindbis viral titers and promote metabolic homeostasis in infected human hepatocellular carcinoma cells
Alphaviruses (Sindbis virus, Chikungunya virus, Ross River virus, and Mayaro virus) are responsible for frequent endemic outbreaks worldwide, impacting more than 100 million people, and are continually spreading. Viruses are pathogens that invade host cells and can seize control over mitochondrial metabolism to increase the production of new progeny. The endocannabinoid system targets cellular pathways that promote metabolic stability and cell survival. The ligands responsible for stimulating the cannabinoid 1 receptor (CB1) could potentially interfere with the efficiency of viral progeny ...
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