Effects of co-activation of cannabinoid type 2 and estrogen receptors on osteogenesis in cultured primary human osteoblasts
Postmenopausal osteoporosis develops when bone removal by osteoclasts exceeds bone formation by osteoblasts due, in part, to the loss of the bone protective effects of high serum estrogen. As with estrogen, activation of the cannabinoid type 2 (CB2) receptor is bone protective, thus co-activation of CB2 and estrogen receptors might enhance osteogenesis in primary human osteoblasts (HOBs). We hypothesize that activation of CB2 receptors in isolation will increase HOB differentiation and osteogenesis in HOBs isolated from a 64-year-old, healthy, female (PromoCell, Germany), and that coactivation ...
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