Congenital heart defects are a relatively common problem, yet the cause is unknown in the large majority of cases. A significant amount of past research has shown that there is a link between altered blood-induced mechanical ...

Osteosarcoma is the most common type of primary bone tumor in humans. Treatment usually involves both surgical resection of the tumor and chemotherapy. Limb sparing often necessitates the use of massive bone allografts, ...

Implantation of a bileaflet mechanical heart valve (BMHV) continues to be associated with risk of thromboembolic complications despite anti-coagulation therapy. Mechanical heart valves have been the gold standard in valve ...

Heart disease is the number one killer in the United States. Within this sector, valve disease plays a very important role: Approximately 6% of the entire population has either prolapse or stenosis of the mitral valve and ...

In this work, we hypothesize scAAVIGF-I can be efficiently engineered and used as a gene therapeutic vector to transduce cartilage and synovium and elicit biochemical changes consistent with cartilage repair mechanisms. ...

Biopolymers are useful in tissue engineering due to their inherent biochemical signals, including interactions with growth factors. There are six biopolymers used in this work, the glycosaminoglycans (GAGs), heparin (Hep), ...

Cardiovascular disease is the leading cause of mortality and morbidity in the United States and other developed countries. In the United States alone, 8 million people are diagnosed with peripheral arterial disease per ...