Rollins, Samuel Burke, authorWilliams, Robert M., advisor2022-11-282022-11-281997https://hdl.handle.net/10217/235832A novel synthetic route to the benzazocine framework of the antitumor antibiotic FR 900482 is presented. The synthesis of the benzazocine ring is characterized by a convergent asymmetric strategy. Although the benzazocine ring was not elaborated into the bicyclic skeleton of the natural product, synthesis of a hitherto unknown class of latent mitosenes was accomplished. Acylation of the benzazocine nitrogen with a photo cleavable protecting group allowed for the formation of the highly reactive mitosene under non-reductive conditions.doctoral dissertationsengCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.Antineoplastic antibioticsOrganic compounds -- SynthesisText