Newkirk, Tenaya L., authorWilliams, Robert M., advisorStermitz, Frank R., committee memberFerreira, Eric M., committee memberRickey, Dawn, committee memberThamm, Douglas H., committee member2022-11-282022-11-282009https://hdl.handle.net/10217/235858Herein are documented our efforts in two projects, beginning with studies towards the total synthesis of 14-acetoxygelsenicine. We have developed different strategies towards this complex natural product, wherein we have developed routes towards an appropriate substrate for a novel, intramolecular hetero Diels-Alder cyclization. The developed route would also lead to related members of this family of alkaloids, and helps set the stage for future efforts. In the second project discussed, we have successfully pursued the synthesis of numerous, biologically active analogs of the natural product (+)-largazole. Synthetic efforts have led to the design of inhibitors with unprecedented biological activity, as well as providing information regarding the structure-activity relationship of these molecules.doctoral dissertationsengCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.Alkaloids -- SynthesisDiels-Alder reactionText