Paris, Hunter Louis Ross, authorBell, Christopher, advisorMelby, Christopher, committee memberHickey, Matthew, committee member2007-01-032007-01-032014http://hdl.handle.net/10217/84047INTRODUCTION: Weight regain after weight loss is the experience of most obese dieters. Metabolic adjustments characterized by decreased resting metabolic rate (RMR) and increased hunger can prevent long-term success. Possibly this energy gap could be attenuated by a high flux (HF) state (higher expenditure coupled with higher intake). METHODS: 6 obese adults [age (mean±SE) = 42±12 y; body mass index (BMI)=35.7±3.7 kg/m2] underwent 7% diet-induced weight loss and were stabilized at this weight for 3 weeks. RMR via indirect calorimetry, and hunger via visual analog scale were then examined during two 4-day conditions of energy balance in random order--Low Flux (LF): sedentary with energy intake (EI)=RMR x1.35; and HF: daily exercise net energy cost of ~500 kcal/d and EI= RMR x1.7. RESULTS: Average 5-day weight did not differ between HF (103.4±4.7 kg) and LF (103±4.8 kg) (P>0.10). Average daily RMR was higher during HF (1926±138 kcal/day) compared to LF (1847±126 kcal/day; P = 0.05). Resting fat oxidation was also higher during HF (0.073+0.010 g/min) compared to LF (0.059+0.012 g/min; P<0.05). Average daily, perceived end-of-day hunger was lower during HF compared to LF (P<0.05). CONCLUSION: These preliminary data suggest that compared to a sedentary LF state of energy balance, a HF energy balance state is associated with a greater RMR, resting fat oxidation, and less hunger - all of which may attenuate the energy gap and protect against weight regain.born digitalmasters thesesengCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.energy balanceweight lossobesitymetabolismText