TRPV1 Activation Counters Vascular Dysfunction by Increasing PPARs, SiRT-1, PGC-1α and UCP-1 Expression in the Thoracic Aorta
Obesity foreshadows metabolic diseases. The imbalance between energy intake and expenditure leads to increased visceral fat accumulation, causing obesity. Vascular dysfunction associated obesity causes hypertension and progressively leads to cardiovascular diseases. Recent research suggests that activating TRPV1 is a good strategy to counter obesity and metabolic complications. In this work, we evaluated a hypothesis that activation of transient receptor potential vanilloid subfamily 1 (TRPV1) expressed in the thoracic aorta vasculature suppresses development of hypertension and vascular damage ...
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