Hydrogel-based Janus Structures for Asymmetrical Aster Nucleation
Microtubule networks control the spatial and temporal dynamics of a host of cellular processes including motility and division. These networks are nucleated at centrosomes anchored to the nuclear membrane. The distribution and density of centrosomes are therefore hypothesized to influence cellular function. This talk describes the production of immobilized and mobile hydrogel structures to serve as sites for the nucleation of microtubule asters. The surfaces of these structures have been asymmetrically decorated with beads which serve as surrogates for artificial centrosomes through a combination ...
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