Cloning, Expression, Purification and Characterization of Brucella abortus Auto-transporter Genes and Their Products
Brucellosis is an economically important cause of abortions in livestock and wildlife worldwide caused by the facultative intracellular pathogen Brucella abortus. One understudied molecular mechanism of in-vivo survival used by B. abortus is adherence to target cells by Type-V (auto-transporting) proteins. BruAb1_1988 and BruAb1_1989 are two such proteins that have been identified within a Cluster of Orthologous Groups (COGs) of proteins expressed in-vivo during infection. Attempts to express BruAb1_1989 have been unsuccessful. A bioinformatics approach, including a 3-D structural analysis, has ...
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