Contribution of the Intestinal Microbiome to the Development of Hirschsprung's-Associated Enterocolitis
Hirschsprung's disease (HD) is a congenital malformation of the gastrointestinal tract characterized by the absence of the distal enteric nervous system. Hirschsprung's-associated enterocolitis (HAEC) is one of the most serious complications of HD. It is hypothesized that the intestinal microbiome contributes to the development of HAEC in human subjects. Our experimental design is to enroll five HD patients after they were diagnosed with HAEC. Fecal samples will be collected prior to antibiotic treatment, after completion of antibiotic treatment, three months after treatment and six months after ...
(For more, see "View full record.")