FSHR-1 and Innate Immunity
Innate immunity is critical for all organisms against microbial pathogens. It is the first line of defense that organisms possess and is used in the activation of adaptive immune response in mammalian vertebrates. Many pathways have been identified as being key to innate immunity regulation. Recently a G protein coupled receptor, FSHR-1, was identified as being important to the function of innate immunity of the nematode Caenorhabditis elegans. Over expression of FSHR-1 makes organisms hyper resistant to killing by pathogenic bacteria while under expression makes organisms hypersensitive to ...
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