Effects of oral supplementation with L-citrulline on recovery from myocardial infarction in mice
In the heart, L-arginine can be metabolized to nitric oxide and citrulline or to urea and ornithine. During a heart attack, the heart undergoes enzymatic changes resulting in a down regulation of the nitric oxide pathway and an induction of the ornithine pathway. Nitric oxide is a vasodilator and improves cardiomyocyte contractility. Thus, an increase in nitric oxide should contribute to a shortened recovery time after a heart attack. We tested the hypothesis that increased blood levels of citrulline, a precursor of arginine, would increase cellular levels of arginine and the local concentration ...
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