Spectroscopic detection of Z-DNA in short oligonucleotides
The structure of right-handed double helical DNA was discovered in 1953 by James D. Watson and Francis Crick. DNA is known to exist in many possible conformations that include A-DNA, B-DNA, C-DNA, D-DNA and Z-DNA. The right-handed B-DNA is the predominant form in biological systems. The B-to-Z-DNA conformation transition is well studied process by which the right-handed duplex turns into a left handed helix known as Z-DNA (zig-zag DNA). Z-DNA exists as a higher energy state of the canonical B-DNA. Recent studies suggest that Z-DNA plays a role in replication and transcription processes. Our ...
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