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dc.contributor.advisorNavratil, Amy
dc.contributor.authorBrant, Jason E.
dc.contributor.authorBrant, Jason E.
dc.date2017-12-01
dc.date.accessioned2018-06-10T21:36:20Z
dc.date.available2018-06-10T21:36:20Z
dc.description.abstractIschemic heart conditions are some of the most prevalent disorders in the United States. These diseases also cause a significant number of mortalities each year. Despite considerable advances in treatment of the ischemic and infarct heart, many patients still develop complications and often progress to heart failure. These outcomes are typically related to factors such as the inability to deliver medication to the affected area, lack of successful stem cell implantation, improper tissue regeneration, and additional damage caused after reperfusion to ischemic tissues. The use of nanotechnology in the treatment of the ischemic and infarct heart has shown promising results for therapeutic improvement. This review focuses on several nanotechnology-based treatments for ischemic heart diseases including simple and modified drug/stem cell delivery systems ranging from magnetic, antibody-linked, and mesoporous silica nanoparticles. Additional nanotechnology systems such as nanoscaffolds and graphene compounds assist the repair of damaged cardiac tissue, therefore, increasing treatment efficacy. Based on these technologies, future models such as multi-functional nanoparticles should be considered for further advancement in this area.
dc.identifier.urihttps://hdl.handle.net/20.500.11919/1437
dc.languageEnglish
dc.publisherUniversity of Wyoming. Libraries
dc.relation.ispartofHonors Theses AY 17/18
dc.relation.ispartofHonors Theses AY 17/18
dc.sourceHonors Theses AY 17/18
dc.subjectCAD
dc.subjectcoronary artery disease; IHD
dc.subjectischemic heart disease; IR
dc.subjectischemic reperfusion; MI
dc.subjectmyocardial infarction; MSC
dc.subjectmesenchymal stem cell; nano-DDS
dc.subjectnanoparticle-mediated drug delivery system.
dc.subjectNanomedicine
dc.titleNanotechnology-Based Drug Delivery/Treatment Methods for Ischemic Heart Diseases
dc.typeThesis
thesis.degree.disciplineZoology and Physiology


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