RNA sequencing analysis reveals the GnRH induced citrullinome
Peptidylarginine deiminases (PADs) are a family of Ca2+ dependent enzymes that post-translationally convert positively charged arginine into neutral citrulline on histone tales to decondense chromatin and change gene expression. Our past work has established that gonadotropin releasing hormone (GnRH) stimulates PAD catalyzed citrullination of histones in gonadotropes, yet the physiological consequence of this on reproductive function are unknown. To address this, we sought to identity of the full cohort of genes regulated by citrullintation in gonadotrope cells. First, the gonadotrope derived ...
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