EXCEEDING THE BIOCHEMICAL SPEED LIMIT OF FIBRINOLYSIS USING MAGNETICALLY POWERED MICROWHEELS
The biochemical lysis of blood clots, or thrombolysis, using tissue plasminogen activator (tPA) is an effective treatment option for some types of clots, but its use has been limited by its rate of transport to and dissolution of thrombi. This thesis develops a technology that could broaden the indications for thrombolytic therapy using rotating magnetic fields to assemble and direct drug-bearing microwheels (μwheels) to target and lyse blood clots.μWheels driven by rotating magnetic fields translate because of friction against a surface. The translational velocity of μwheels depends on the ...
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