Applying mathematical models of human circadian rhythms for experimental design and data analysis
The adult human circadian pacemaker has an intrinsic period just over 24 h that entrains to a 24 h day by environmental cues such as light, eating, and exercise. Dynamic phenomenological mathematical models of the human circadian pacemaker have been developed to simulate the pacemaker's response to light. These models have been widely used for applications such as minimizing jet lag and optimizing experimental protocol design. This thesis is focused on applying mathematical models to account for the interindividual differences that are inherently present in humans and therefore also in circadian ...
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