Synthesis of poly(lactide)-based amphiphilic block copolymers and hydroxyapatite nanoparticles for bone tissue engineering applications
Due to the drawbacks associated with traditionally used bone substitutes, such as autografts and allografts, the field of tissue engineering, regenerative medicine and biomaterials science has recently come to the forefront with new strategies for bone repair and de novo tissue formation. Current research has focused on employing bionanocomposites composed of polymers, such as poly(lactide) (PLA), and inorganic calcium phosphate ceramics, such as hydroxyapatite (HA). These hybrid materials benefit from combining biodegradability, biocompatibility, bioactivity, and other advantageous scaffold ...
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