Hydrophilic and cationic polymers as potent antimicrobial materials: another pathway to fight tough bacterial infections
Membrane-active antimicrobial peptides and their synthetic mimics have been studied extensively as a new generation of antibiotics to fight against the persistent evolution of pathogens that resist traditional antibiotic treatment. It has long been recognized that a delicate yet un-quantified balance between amphiphilicity and cationic charge is key to optimize the bactericidal efficiency and selectivity of these membrane-active antimicrobials (MAAs). The dilemma, however, is that the amphiphilic nature of MAAs that gives rise to their potency in disrupting microbial membranes is oftentimes also ...
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