Combination of hydrodynamic and optical forces for cell mechanical flow cytometry
Cell mechanical properties are a label-free biomarker capable of differentiating between healthy and diseased cells. Currently, cell deformability is measured by testing the mechanics of a suspension of cells to yield population averaged properties. This approach can mask the presence of sub-populations of diseased cells. Alternatively, individual cell measurements provide detailed information of individual cells, but are inherently low throughput, making data acquisition tedious and scale-up impractical. To address these issues, we propose using optical-based cell deformation techniques in ...
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