Synthesis of pH-responsive polymers via RAFT polymerization and their use for preparation of pH-responsive MRI contrast agents
Despite recent advances in the understanding of fundamental cancer biology, cancer remains the second most common cause of death in the United States. One of the primary factors indicative of high cancer morbidity and mortality and aggressive cancer phenotypes is tumors with a low extracellular pH (pHe). Thus, the ability to measure tumor pHe in vivo using non-invasive and accurate techniques that also provide high spatiotemporal resolution has become increasingly important and is of great interest to both researchers and clinicians. Recently, the use of pH-responsive polymer systems in cancer ...
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