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dc.contributor.advisorGavett, Brandon E.
dc.contributor.authorLin, Shayne Shih-Hsuan
dc.contributor.committeememberKisley, Michael A.
dc.contributor.committeememberFletcher, Evan
dc.date.accessioned2019-05-17T19:43:10Z
dc.date.available2019-05-17T19:43:10Z
dc.date.submitted2019-05
dc.descriptionIncludes bibliographical references.
dc.description.abstractThe Reliable Change Index (RCI) is a commonly used method for interpreting change in neuropsychological test scores over time. However, the RCI is a psychometric phenomenon that, to date, has not been validated by neuroanatomical evidence. Longitudinal neuroimaging and neuropsychological data from baseline and one-year follow-up visits were retrieved from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. The RCI was used to identify participants showing reliable decline on the Auditory Verbal Learning Test (AVLT) delayed recall, the Trail Making Test part B (TMT-B), the ADNI-MEM and the ADNI-EF, the latter two of which provide composite measures of memory and executive functioning, respectively. For each cognitive test score, two groups (reliable change vs. no reliable change) were matched on potential confounding variables using a genetic algorithm. Longitudinal neuroanatomical data were analyzed using tensor-based morphometry (TBM). The AVLT delayed recall was not associated with any significant voxel changes in TBM analysis and the matching procedure for the TMT-B was unable to find two equivalent groups. In contrast, TBM analysis revealed that reliable change on ADNI-MEM was associated with atrophy of the temporal lobe, the medial temporal cortex, and some parts of the parietal lobe. Similar atrophy patterns were found for reliable change on ADNI-EF, except that the atrophy was more extensive and of higher magnitude and also involved the frontal lobe. Regional analysis further confirmed that in such brain regions, the reliable change group manifested higher grey matter loss than the no change group. Overall, the current research not only validated clinical usage of the RCI with neuroanatomical evidence but also practically suggested patterns of likely brain atrophy when reliable cognitive decline is detected.
dc.identifierLin_uccs_0892N_10478.pdf
dc.identifier.urihttps://hdl.handle.net/10976/167112
dc.languageEnglish
dc.publisherUniversity of Colorado Colorado Springs. Kraemer Family Library
dc.relation.ispartofTheses
dc.rightsCopyright of the original work is retained by the author.
dc.subjectLongitudinal study
dc.subjectReliable Change Index
dc.subjectExecutive functions
dc.subjectTensor-based morphometry
dc.subjectMemory
dc.titleValidating the Reliable Change Index with Tensor-Based Morphometry
dc.typeText
dcterms.cdm.subcollectionPsychology
thesis.degree.disciplineCollege of Letters, Arts, and Sciences-Psychology
thesis.degree.grantorUniversity of Colorado Colorado Springs
thesis.degree.levelMasters
thesis.degree.nameMaster of Arts (M.A.)


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