HOW DOES THE RNA BINDING PROTEIN CAPER INFLUENCE DROSOPHILA LOCOMOTOR BEHAVIOR AND LONGEVITY?
Neuronal morphology is critical for correct wiring and function of the nervous system. Dysmorphic neurons are directly correlated with many neurodegenerative diseases, including ALS, yet the genetic basis for many of these heritable diseases is not understood. Recently, RNA regulatory mechanisms have increasingly been implicated in myriad neurological disorders. RNA binding proteins (RBPs) mediate RNA regulatory mechanisms, such as splicing. Caper, an RBP and splicing factor, is a candidate gene for studying these processes. Using the Gal4-UAS and RNA interference (RNAi) technologies, we knocked ...
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