Relationship Between Dendritic Cell Maturation and Exosome Content and Function, The
Dendritic cells (DCs) are a type of regulatory immune cell that shape the nature and duration of an immune response. DCs exist in an immature state and upon the detection of pathogens via Toll-like receptors (TLR), endocytose the pathogen, mature, and differentiate into sub-classes of cells with immunostimulatory or immunosuppressive roles. DCs are the most potent antigen-presenting cell (APC) to induce T-cell activation through the up-regulation of co-stimulatory molecules, antigen-presenting molecules, and cytokine secretion. Exosomes are nanovesicles secreted by most cells and serve critical ...
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