Now showing items 1-7 of 7
Functional genomics approach to identifying driver and auxiliary survival pathways in head and neck squamous cell carcinomas and non-small cell lung cancers, A
Contributor:Singleton, Katherine Renee
Head and neck squamous cell carcinoma (HNSCC) and non-small cell lung cancer (NSCLC) are tobacco-related malignancies of the aero-digestive tract. HNSCC is characterized by a distinct lack of targetable oncogenic mutations, ...
Graphical model methods for integrating diverse sources of genome-scale data
Making effective use of multiple data sources is a major challenge in modern bioinformatics. Genome-wide data such as measures of transcription factor binding, gene expression, and sequence conservation, which are used ...
Differential correlation in high-throughput data
Contributor:Siska, Charlotte Julia
Differential correlation or coexpression occurs when feature pairs (e.g. transcripts, proteins, or metabolites) have different types of associations between biological groups. Differentially correlated feature pairs may ...
Translational approaches to predicting tuberculosis risk: from administrative data to transcriptional biomarkers
Contributor:Walter, Nicholas David
Tuberculosis (TB) is an ongoing global public health crisis. In 2013, approximately 9 million people developed active TB and 1.5 million died. This dissertation addresses high-priority challenges in risk prediction, diagnosis ...
Systems approach to respiratory disease, A
Contributor:Garcia, Benjamin J.
Systems-based approaches, including genomics, interactomics, and transcriptomics, allow for more comprehensive and more generalizable analyses than single gene or single drug approaches. These approaches often utilize ...
Statistical methods for detecting allelic imbalance in RNA-Seq data
Contributor:Jacobson, Sean Robert
Gene expression studies are a key component of investigations related to identification and characterization of genetic risk factors for disease. Gene expression refers to the abundance of messenger ribonucleic acid (mRNA) ...
DNA methylation changes in allergic airway disease
Asthma is a complex chronic inflammatory respiratory disease with a diverse phenotype defined by clinical, physiological, and pathological characteristics. It poses a significant health and socioeconomic burden with 1 out ...