Now showing items 1-10 of 317
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Functional roles of pulmonary dendritic cell subsets
Author(s):Desch, Ashley Nicole
Pulmonary dendritic cells (DCs) constantly sample tissue and traffic inhaled antigens to the lung-draining lymph node (LN) where they orchestrate an appropriate immune response. The immunologic outcome of antigen-presentation ...
Structural and mechanistic analysis of IRES driven translation initiation from the 5' leaders of HIV-1 transcripts
Internal ribosome entry site (IRES) RNAs are important regulators of gene expression, but their diverse molecular mechanisms remain partially understood. The HIV-1 gag transcript leader contains an IRES that may be a good ...
Novel approaches in the treatment for glioblastoma multiforme
Author(s):Sufit, Alexandra JD
Glioblastoma multiforme is a dismal disease with a prognosis of 12-14 months following diagnosis. Patients diagnosed with this disease have a <5% 5-year survival rate. Unfortunately, these statistics have not changed in ...
Role of the placenta in health and disease investigations into Siglec-6 and exosomes, The
Author(s):Stefanski, Adrianne Lee
The placenta plays a critical role in the success and maintenance of pregnancy in eutherian mammals. During placental development, placental trophoblasts come into direct contact with maternal cells including those of the ...
Immune regulation of mammary gland involution reveals targets for postpartum breast cancer treatment
Author(s):Martinson, Holly Anna
Women within 5 years postpartum have increased incidence of breast cancer as well as a poorer prognosis compared to women who have never been pregnant. Our lab has proposed that the poor prognosis and increased incidence ...
Thermodynamic dissection of estrogen receptor-α self-association and promoter assembly energetics suggests dimerization energetics drives promoter assembly
Author(s):Moody, Amie D.
The steroid receptor family of ligand-activated transcription factors provides an excellent model system to study the quantitative mechanisms of eukaryotic transcriptional regulation. A biochemical model describing the ...
Exploring nicotinic receptor-mediated GABAergic mechanisms in the mouse main olfactory bulb
The olfactory bulb (OB) receives cholinergic inputs that arise from the basal forebrain. Cholinergic network activity has been related to processes that involve attention and arousal. In recent years, the cholinergic system ...
Interprofessional collaboration between midwives and physicians
Author(s):Smith, Denise Colter
Healthcare delivery in the United States is rapidly changing and collaborative practice models have been cited as an approach to improving efficiency and effectiveness, reducing cost and maintaining safety and quality. ...
Biochemical regulation of the CaMKII/GluN2B interaction and its role in the maintenance of synaptic strength
Author(s):Barcomb, Kelsey Marie
Ca²⁺/Calmodulin (CaM)-dependent protein kinase II (CaMKII) is a major regulator of long-term potentiation (LTP) in the hippocampus. During this process, CaMKII becomes activated and translocates to the activated synapse ...
Genome-wide mapping of the DNA modification uracil and its mechanism of incorporation into DNA
Author(s):Bryan, Debra Suzi
The incorporation and creation of modified nucleobases in DNA have profound effects on genome function. In this study, we developed a novel, specific method for mapping positions and local content of modified DNA nucleobases ...