Now showing items 1-10 of 11
Pharmacokinetics and renal safety of tenofovir with ledipasvir/sofosbuvir
Author(s):Kiser, Jennifer Justice
Individuals may be infected with Hepatitis C Virus (HCV) and the Human Immunodeficiency Virus (HIV) due to shared routes of transmission. HCV is curable with 8-12 weeks of direct-acting antiviral (DAA) therapy. However, ...
Re-linkage to HIV care among persons living with HIV (PLWH) with a gap in care of six months or more
Author(s):Mignano, Jamie Lynn
Despite widespread attention to the HIV care continuum over the past several years, little attention has focused on the 45% of PLWH that are not retained in care who are responsible for more than 60% of new HIV infections. ...
Marijuana use on quality of life outcomes in HIV-infected men
Author(s):Gross, Lilyana L.
Methods: Data were from 1458 HIV-infected participants on HAART in the Multicenter AIDS Cohort Study from 2001 to 2008. Physical and mental quality of life (QoL) measures, defined by the Short Form 36 (SF-36) survey, were ...
Structural and mechanistic analysis of IRES driven translation initiation from the 5' leaders of HIV-1 transcripts
Internal ribosome entry site (IRES) RNAs are important regulators of gene expression, but their diverse molecular mechanisms remain partially understood. The HIV-1 gag transcript leader contains an IRES that may be a good ...
Impact of IDU on HIV viral load after treatment initiation taking into account left-censoring and nonignorable dropout
In HIV clinical trials and longitudinal cohort studies, injection drug users (IDU) are an important part of the study population. On highly active antiretroviral therapy (HAART), HIV viral loads (a biomarker for HIV disease ...
Role of APOBEC3 in the neutralizing antibody response to Friend retrovirus, The
A vaccine that elicits HIV-1 broadly neutralizing antibodies (bNAbs) could significantly lower the risk of infection. However, HIV-1 bNAbs exhibit unprecedented levels of somatic hypermutation (SHM) and often have essential ...
Factors associated with retention in care for persons living with HIV in non-urban Western Colorado
The vast majority of people living with HIV are not retained in regular care, although retention in care is critical to reducing HIV-associated morbidity and mortality. Current research on retention in HIV care is heavily ...
B cell subset contributions to the primary HIV antibody response
Despite global efforts, a preventative HIV vaccine remains elusive. The correlates of protection against HIV infection are as yet undefined, but clues can be drawn from potent antibodies able to neutralize diverse HIV ...
Role of follicular regulatory T cells in HIV and SIV pathogenesis, The
Author(s):Miller, Shannon Marilee
During chronic HIV infection, virus replication is concentrated in secondary lymphoid follicles, specifically in follicular helper T cells (TFH). The germinal center (GC) reaction is dysregulated during chronic HIV infection. ...
Knot selection strategies for semiparametric varying coefficient models applied to longitudinal cohorts with multiple dropout reasons
Author(s):Moore, Camille Marie
Dropout is a common source of missing data in longitudinal studies, and often occurs for reasons that may be related to an outcome of interest. When dropout depends on unobserved outcomes, even after conditioning on ...