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Developmental origins and heterogeneity of the neocortical oligodendrocyte lineage
Author(s):Winkler, Caitlin
Date Submitted:2019
The formation of neocortical circuits during development requires coordinated production of excitatory projection neurons, astrocytes, and oligodendrocytes from a shared pool of neural progenitor cells. While we are beginning ...
Characterizing MIR137HG variation and contribution to risk for schizophrenia
Author(s):Pacheco, Ashley
Date Submitted:2019
The MIR137HG gene encoding microRNA-137 (miR-137) is associated with risk for schizophrenia (SZ) through genetic and functional studies, however, the molecular mechanisms underlying risk remain unknown. Through this work ...
Reward processing in healthy adolescents and adolescents with Anorexia nervosa
Author(s):Deguzman, Marisa
Date Submitted:2019
Anorexia nervosa (AN) is a severe eating disorder that predominantly affects young females and typically begins in adolescence. These studies aimed to understand the underlying neurobiology of adolescent AN by assessing ...
Comparison of two-stage FPCA and bayesian mixture models applied to physical activity accelerometer data : pattern identification and group classification, A
Author(s):Cotton, Eleanor R.
Date Submitted:2019
Collectively, society has begun to borderline obsess with ability to monitor our physical activity. A plethora of devices now exist to monitor steps, heart rate, sleep pattern, and many other metrics, giving individuals ...
High altitude pregnancy as a model for uteroplacental hypoxia : identifying therapeutic targets for preventing fetal growth restriction
Author(s):Coates, Sydney Louise
Date Submitted:2019
Arguably a population with the greatest unmet need for therapies is pregnant women. Despite the risk of maternal and offspring perinatal morbidity and “programming” of adult disease in the offspring, there is a lack of ...
Building a brain : interrogating how the α-tubulin gene TUBA1A contributes to neurodevelopment
Author(s):Aiken, Jayne
Date Submitted:2019
The importance of microtubules during the development and appropriate function of the nervous system has long been acknowledged. The highly complex coordination of cell proliferation, differentiation, migration, neuronal ...
Mechanisms of immunoglobulin somatic hypermutation during retroviral infection
Author(s):Jones, Sean Taylor
Date Submitted:2019
A potential HIV-1 vaccine should stimulate a broadly neutralizing antibody (bNAb) response, which overcomes HIV-1 mutational escape to typical NAb responses that develop by covering a wide variety of HIV-1 strains. bNAbs ...
Supine sleep positioning among high-risk U.S.-born infants : the persistent preterm/term and non-Hispanic black/non-Hispanic white racial disparity
Author(s):Hwang, Sunah
Date Submitted:2019
Objectives: 1) Assess the racial disparity in SSP between NHB and NHW early preterm (<34 weeks) and late preterm (34-36 weeks) infants, 2) Measure the impact of states’ prioritization of safe infant sleep in their 2010 ...
High incidence of SMAD4 loss and associated susceptibility to combined PARP inhibition with radiation in head and neck squamous cell carcinomas
Author(s):Hernandez, Ariel
Date Submitted:2019
SMAD4 loss is associated with increased survival and genomic instability, and contributes to the initiation/progression of head and neck squamous cell carcinoma (HNSCCs). SMAD4 loss, while not directly targetable, is ...
Centrosome number homeostasis : lessons from CEP135 isoform dysregulation in breast cancer
Author(s):Ganapathi Sankaran, Divya
Date Submitted:2019
The centrosome, comprised of two centrioles surrounded by pericentriolar material, is the cell’s central microtubule organizing center. Centrosome duplication is coupled with the cell cycle such that centrosomes duplicate ...