PAH mixture exposures may drive mixture specific monocyte immune responses through modifications to monocyte metabolomes
Generated during incomplete combustion of carbon sources, polycyclic aromatic hydrocarbons (PAHs) have been shown to lead to both lung and digestive tract cancers. Exposures to benzo[a]pyrene (B[a]P), a group I carcinogen and the model PAH, has been shown to alter the immune response by suppressing B cells, T cells, monocytes, and macrophage functions. However, PAHs are generated and encountered by humans as mixtures. While excellent work has been performed delineating immune suppression following real-world combustion mixture exposures and defining alterations to the immune responses for ...
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