Single cell analysis of biochemical phenotypes
Recent development of high throughput single cell methods has expanded our understanding of tissue heterogeneity, cell states, and developmental biology. Current single cell methods aim to understand cell function and phenotype by measuring a variety of cell features, like DNA sequence, mRNA abundance, chromatin accessibility, cell surface proteins, and histone modifications. However, cell phenotypes are regulated by a number of factors that escape the abundance measurements of current single cell methods. To directly measure cell phenotypes, I developed a method to measure enzyme activities in ...
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