Interactions at the interface- mechanisms of capsular polysaccharide communication with the host in intestinal bacteroides
Millenia of co-evolution have shaped the relationships between humans and microbes, and signatures of these interactions can be found in the physiology of each. This thesis looks directly at host and microbial factors at the site of interface in the intestinal milieu. We specifically explore the mechanisms driving capsular polysaccharide communication with the host in intestinal Bacteroides and examine a role for host blood glycans in shaping the resident Bacteroides population. Bacteroides fragilis, an important clinical pathobiont, produces a zwitterionic capsular polysaccharide (ZPS) named ...
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