Variable IL-2Rβ expression and organization in signaling and disease
Delivery of recombinant IL-2 and IL-15 and the targeting of their receptors has emerged as a promising intervention strategy for treatment of autoimmunity, chronic infectious diseases and cancer. Therefore, a better understanding of IL-2/IL-15 biology is necessary, especially in respect to signal transduction. Even though IL-15 and IL-2 have distinct immunological functions, they both signal through receptor subunits, IL-2Rβ and γc. While work has shown that cell type-specific differences in IL-2Rβ abundance have a key role in tuning tolerogenic and immunogenic responses, the role of differential ...
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