Targeting the SIX1/EYA complex in breast cancer metastasis
Metastasis is the number 1 killer of cancer patients and mis-regulation of developmental signaling pathways can dramatically affect this process. The SIX1/EYA transcriptional complex, a master early development regulator, is typically silenced or down-regulated post-development. However, its abnormal re-expression in adult tissue can facilitate tumor progression. SIX1, in large part through partnering with the co-factor EYA proteins, stimulates metastasis of breast cancer. It does so via numerous means, including activation of TGF-β signaling and induction of an epithelial-mesenchymal transition ...
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