Integrative network analysis of host-transcriptome, microbiome and microbial translocation markers in chronic HIV-1 infection
Human Immunodeficiency Virus-1 (HIV-1) infection targets gut-associated lymphoid tissues as major sites of viral transmission, replication and spread, resulting in CD4+ T cell depletion, gut mucosal damage and disease progression. The accompanying translocation of microbial products and potentially microbes themselves from the lumen into the systemic circulation during HIV-1 infection is known as microbial translocation (MT). It is increasingly recognized that the interaction between microbes and host responses via MT results in immune activation. However, the specific bacterial genera that are ...
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