Investigating the physicochemical and immunogenic properties of freeze-thaw stressed Alhydrogel® and the adjuvanticity of mesoporous silicas for a recombinant hepatitis B surface antigen vaccine
Many vaccines contain purified antigens that have excellent safety profiles; however, they require adjuvants to elicit a robust immune response. Aluminum- containing adjuvants, which were developed in 1926, are the most commonly used adjuvants in FDA-approved vaccines. Although there is a long history of adjuvant use, we are only beginning to gain important insight into the fundamental properties of particulate adjuvants for their immune stimulating activity. The focus of this thesis is to (1) understand the physicochemical and immunogenic properties of aluminum-containing adjuvants and (2) ...
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