Structural and mechanistic analysis of IRES driven translation initiation from the 5' leaders of HIV-1 transcripts
Internal ribosome entry site (IRES) RNAs are important regulators of gene expression, but their diverse molecular mechanisms remain partially understood. The HIV-1 gag transcript leader contains an IRES that may be a good model for understanding the function of many other IRESs. I investigated the possibility that this IRES' function is linked to both the structure of the RNA and its cellular environment. Examining this IRES' activity in a variety of different cell types, I demonstrate that the HIV-1 gag IRES' activity is cell type-specific, with higher activity in T-cell culture systems that ...
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Kieft, Jeffrey S.
Access restricted until November 30, 2014.