Effects of antimicrobial preservatives on the partial unfolding and aggregation of model and pharmaceutical proteins
Multi-dose protein therapeutics compose approximately one-third of all protein-based drugs on the worldwide market. These formulations include at least one antimicrobial preservative (AP) to combat the growth of bacteria and other microbes during repeated contact between the solution and syringe needle. While multi-dose therapeutics are beneficial in terms of patient compliance and economics, the necessary inclusion of APs has been linked to protein aggregation in the liquid state. However, the mechanism of AP-induced protein aggregation remains unclear. In this work we examine the effects of ...
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Bis, Regina L.
Mallela, Krishna M.G.
Access restricted until May 31, 2015.