Semaphorin 7A drives breast cancer progression through intrinsic and extrinsic mechanisms
Breast cancer (BC) remains the second leading cause of cancer-related deaths for women in the US—mainly due to metastatic disease. Additionally, women aged <45 who are within 5-10 years of most recent childbirth at BC diagnosis are ~3 times more likely to develop metastasis and die from BC than age- and stage-matched nulliparous patients. We define these cases as postpartum BC (PPBC) and propose that the unique biology of the postpartum mammary gland drives tumor progression. Our published results revealed roles for Semaphorin 7a (SEMA7A), an axon guidance protein, in breast tumor cell growth, ...
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