Convergence and evolving amino acid propensities
Understanding the relationship between structure and function of proteins is essential for studying protein dysfunction and disease and for engineering therapeutic proteins with novel functions. The details of how proteins perform their function and the effects of mutations on that function are two important facets of this relationship. Both protein structure and function have been shaped by evolution and so evolution can inform predictions about protein function and the effects of mutation. One important aspect of protein evolution is the set preferences for each amino acid at every site ...
(For more, see "View full record.")