Gene set enrichment analysis to understand context-specific gene expression
Measuring gene expression, or the genome-wide levels of mRNA molecules in a human cell, provides a rich source of information about the functional pathways and processes active or dysregulated in the cell. Gene expression is context-specific: expression levels of the approximately 20,000 human protein-coding genes can vary widely between cells from different tissue types and can also change under disease conditions or in response to experimental conditions, such as drug treatment. However, while quantifying per-gene expression changes can be useful for identifying individual genes associated ...
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