Inflammatory cytokines as critical regulators of hematopoiesis and leukemia progression
Chronic inflammation, often driven by the pro-inflammatory cytokine IL-1, is commonly found in patients with auto-immune disorders, hematological malignancies, or obesity, as well as in aging individuals. Hematopoietic stem cells (HSCs) exposed to chronic inflammatory stimuli exhibit altered HSC potential and decreased long-term repopulating activity. However, secondary transplant of these HSCs does not result in bone marrow failure, suggesting that some HSCs are able to prevent exhaustion in the face of chronic inflammation. To understand why, we used an IL-1 driven mouse model of chronic ...
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