Identifying rare somatic mutations as a means of understanding tissue clonal evolution
Many general principles governing the development and evolution of cancers have been discovered by measuring how cells within tumors evolve with time. It is however still largely unclear what first steps a cell population must take in order to form a mature malignant cancer. In part, the technical difficulties of measuring and following extremely rare cell populations makes the task of understanding the earliest dynamics in cancer formation a formidable one. One common approach of following the early development of cancer is through next-generation deep sequencing as it facilitates measurements ...
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