Modifications to TRPM2 channel activity following global cerebral ischemia
TRPM2 is a calcium permeable channel activated by ADPR metabolites and oxidative stress. TRPM2 contributes to neuronal injury in the brain caused by stroke and cardiac arrest among other diseases including cancer, inflammation, and pain. However, the lack of specific inhibitors hinders the study of TRPM2 in pathophysiology. Our lab designed tat-M2NX to prevent ligand binding and TRPM2 activation. We performed a structure-activity relationship (SAR) study through mutagenesis of tat-M2NX to determine the antagonistic mechanism on TRPM2 using whole-cell patch clamp and Ca2+ imaging in human embryonic ...
(For more, see "View full record.")